Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer
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چکیده
منابع مشابه
Expression and Clinical Significance of Activating Transcription Factor 3 in Human Breast Cancer
Objective(s): Breast cancer is the most common type of cancer among women worldwide. This study investigated the expression and clinical significance of activating transcription factor 3 (ATF3) in human breast cancer and its relationship with the clinical outcome of breast cancer. Materials and Methods : ATF3 expressions were detected in 114 primary breast cancer tissues and ...
متن کاملexpression and clinical significance of activating transcription factor 3 in human breast cancer
objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer. materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...
متن کاملKRAS in pancreatic cancer.
Pancreatic cancer is one of the most feared malignancies. The most common form of pancreatic cancer is adenocarcinoma arising from the ductal epithelium. KRAS is the most common oncogene that has been found to be mutated. However, targeting KRAS directly has been difficult. We do not know a lot about the relationship between KRAS and other signaling pathways. At the same time, little is known a...
متن کاملBasic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells.
Basic transcription factor 3 (BTF3) acts as a transcription factor and modulator of apoptosis, and is differentially expressed in colorectal cancer and glioblastomas. In the present study, the expression of BTF3, as well as its role in apoptosis and gene transcription, was analyzed in pancreatic ductal adenocarcinoma (PDAC). QRT-PCR, immunohistochemistry, immunoblotting, and immunofluorescence ...
متن کاملMDM2 mediates ubiquitination and degradation of activating transcription factor 3.
Activating transcription factor 3 (ATF3) is a common stress sensor, and its rapid induction by cellular stresses (e.g. DNA damage) is crucial for cells to mount appropriate responses (e.g. activating the tumor suppressor p53) and maintain homeostasis. Although emerging evidence suggests that dysregulation of ATF3 contributes to occurrences of human diseases including cancer, the mechanism(s) by...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2021
ISSN: 0950-9232,1476-5594
DOI: 10.1038/s41388-021-01771-z